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The first and only amphetamine patch

XELSTRYM:
ADHD treatment
that lets you control

Your time,
Your way
The first and only amphetamine patch

Work with your healthcare provider to determine when to apply and when to remove XELSTRYM to help fit ADHD treatment into your changing schedule.

XELSTRYM should be removed within 9 hours.

Your ADHD treatment should be flexible to meet the demands of your daily schedule

No matter where you are in your day—working, exercising, socializing with friends or family, or just taking some “me” time—symptom management should align with your daily routine. It is important to work with your healthcare provider for flexibility with your schedule.

Starting your day
Presenting at work
“Me” time

What is XELSTRYM?

The first and only amphetamine treatment for ADHD that uses patch technology to passively deliver medication through the skin

XELSTRYM has the same active metabolite (dextroamphetamine) as Vyvanse®*, a medication used to treat ADHD since 2007.

This technology allows you and your healthcare provider to tailor your ADHD treatment to meet your daily schedule. Work with your healthcare provider to determine when to apply and when to remove XELSTRYM.

XELSTRYM should be removed within 9 hours.

There are no head-to-head safety or efficacy studies comparing Vyvanse® and XELSTRYM.
*VYVANSE® is a registered trademark of Takeda Pharmaceuticals U.S.A., Inc.

Digital tools designed to support your patch management routine

Download the Mindful Patch app to help you start and stay on track with personalized patch application and removal reminders!

Download

the Mindful Patch app to start, and stay on track with personalized patch application and removal reminders!

How do I apply the patch?

Watch this video to learn how to use XELSTRYM.

Download the Application Site Quick Reference Guide to learn more about how to use XELSTRYM—or, download the Mindful Patch app for help getting started

XELSTRYM is a clear and discreet patch that can be worn under your clothing

Four dosage strengths provide flexible options

Work with your healthcare provider to tailor your dose to meet your needs.

Patches, US nickel, and golf ball not shown at actual size.

  • Use one patch daily (per 24 hours)
  • Do not wear the patch for more than 9 hours
  • Select a different application site when a new patch is applied
  • See full Instructions for Use

Personalized application reminders

The Mindful Patch app may help you put your patch in the right spot and for the right amount of time each day, based on the plan you and your healthcare provider have aligned on.

Download Mindful Patch

Digital tools designed to support your patch management routine

Download the Mindful Patch app to help you start and stay on track with personalized patch application and removal reminders!

Download

Personalized application reminders

The Mindful Patch app may help you put your patch in the right spot and for the right amount of time each day, based on the plan you and your healthcare provider have aligned on.

XELSTRYM can be worn during most of your daily activities

YESAVOID
Showering*
Bathing*
Swimming*
Activities that cause sweating†
Direct heat‡

*Patients should check to see if the patch has become loose after bathing, showering, or swimming.

†Patients should check their patch fit if they sweat excessively.

‡After applying XELSTRYM, patients should avoid exposing the application site to direct external heat sources, such as hair dryers, heating pads or electric blankets, heat lamps, saunas, hot tubs, and heated water beds. Exposure to heat can cause too much medicine to pass into their body and cause serious side effects.

What are the most common side effects of XELSTRYM in adults?

Decreased appetite Increased blood pressure
Headache Muscle twitching (tics)
Trouble sleeping Vomiting
Stomach pain Irritability
Nausea Increased heart rate

Application site reactions have happened while wearing XELSTRYM and after removal of the patch. Symptoms include pain, itching, burning feeling, redness, discomfort, or swelling at the application site. Call your healthcare provider if you or your child develop any application site reactions that do not resolve on their own.

Savings and support are always within reach

XELSTRYM Copay Savings Program

Click here for pharmacist instructions, eligibility information, and full Terms and Conditions.

Enrolling is quick and easy

Choose 1 of the 2 options below to begin the enrollment process. Enrolling will provide you:

  • Access to copay savings card
  • Potential delivery to your home, free of charge (Noven C.A.N.™ Partner Pharmacies only)
  • Prescription refill reminders via SMS
Enroll
Click the “Enroll”
button to begin
Text “SAVE” to
515-517-6662

You can also register for copay savings and locate partner pharmacies directly through the Mindful Patch app!

The Mindful Patch app can assist with locating partner pharmacies near you to help you access your XELSTRYM prescription.

Download the app
Questions?
The Noven C.A.N. Patient Access Team is here to help

Our dedicated response team can help with every step of the process, whether you need assistance with the XELSTRYM Copay Savings Program or are looking for the closest Noven C.A.N. Partner Pharmacy.

Noven C.A.N. Patient Access TeamCall 833-483-2178 Monday-Friday,
9:00 AM - 7:00 PM EST

Noven C.A.N. Partner Pharmacy FinderEnter a ZIP code below to locate a Noven C.A.N. Partner Pharmacy.

Tools & Resources

The Mindful Patch app

An optional digital companion to help you with your ADHD transdermal treatment journey

Mindful Patch is the first and only digital health tool that helps you start, streamline, and track your XELSTRYM treatment over time.

With Mindful Patch, you can:

  • Set and monitor your medication schedule Customizable patch application and removal reminders help ensure you stick to your treatment plan.
  • Stay informed about your ADHD treatment With real-time tracking of factors related to your ADHD and overall wellbeing, the Mindful Patch app gives you select insights about your ADHD treatment journey that you can share with your healthcare provider.
  • Make the most of your treatment journeyAccess savings offers, informational videos, detailed instructions, and more.

Ready to get more mindful about your ADHD medication? Get the Mindful Patch app today.

Download via the
Apple App Store

Download via the
Google Play Store

Additional Resources

Tools and resources to help you learn more about XELSTRYM

In addition to the features available in the Mindful Patch app, these resources can help you get started—and stay on track—with your ADHD treatment.

close

XELSTRYM Availability Update

A shortage of XELSTRYM (dextroamphetamine) transdermal system, CII (all doses), is expected to begin in the middle of June 2026 with patient impact starting in the middle of July 2026.

Please be assured that our team is working diligently to resolve the situation and restore supply.

To help support continuity of care, patients can visit XELSTRYM Find a Partner Pharmacy Near You or call 800-420-2719 to locate pharmacies that may currently have XELSTRYM in stock while inventory is available.

If you have any questions or would like to speak with someone in the Noven Pharmaceuticals Inc. Medical Information department, please call 800-455-8070 (Monday-Friday, 8:00 AM - 6:00 PM EST) or email noven@druginfo.com.

Please click here for the Medication Guide and Full Prescribing Information, including the BOXED WARNING.

For US audience only.
XEL-35100-16 05/26

Important Safety Information
What is XELSTRYM?

XELSTRYM is a central nervous system stimulant prescription medicine used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD) in adults and children 6 years and older. XELSTRYM may help increase attention and decrease impulsiveness and hyperactivity in adults and children 6 years of age and older with ADHD. XELSTRYM is not recommended for use in children under 6 years of age with ADHD.

IMPORTANT SAFETY INFORMATION

Abuse, misuse, and addiction: XELSTRYM is a federally controlled substance (CII) because it contains dextroamphetamine that can be a target for people who abuse prescription medicines or street drugs. Keep XELSTRYM in a safe place to protect it from theft. Never sell or give your XELSTRYM to anyone else because it may cause death or harm to them and it is against the law. Tell your healthcare provider (HCP) if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Do not use XELSTRYM if you or your child are:
  • Allergic to amphetamine or any of the ingredients in XELSTRYM. See the end of the Medication Guide for a complete list of ingredients in XELSTRYM.
  • Taking or have taken within the past 14 days a medicine called a monoamine oxidase inhibitor (MAOI), including the antibiotic linezolid or the intravenous medicine called methylene blue.
XELSTRYM can cause serious side effects, including:
  • Risks for people with serious heart disease. Sudden death has happened in people who have heart defects or other serious heart disease. Your HCP should check you or your child carefully for heart problems before starting treatment with XELSTRYM. Tell your HCP if you or your child have any heart problems, heart disease, or heart defects. Call your HCP or go to the nearest hospital emergency room right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting during treatment with XELSTRYM.
  • Increased blood pressure and heart rate. Your HCP should check you or your child’s blood pressure and heart rate regularly during treatment with XELSTRYM.
  • Mental (psychiatric) problems. Including new or worse behavior and thought problems; new or worse bipolar illness; new psychotic symptoms (such as hearing voices, or seeing or believing things that are not real); or new manic symptoms. Tell your HCP about any mental problems you or your child have or about a family history of suicide, bipolar illness, or depression. Call your HCP right away if you or your child have any new or worsening mental symptoms or problems during treatment with XELSTRYM, especially hearing, seeing or believing things that are not real, or new manic symptoms.
  • Slowing of growth (height or weight) in children. Children should have their height and weight checked often while on XELSTRYM. Your HCP may stop treatment with XELSTRYM if your child is not growing or gaining height or weight as expected.
  • Circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud's phenomenon). Fingers or toes may feel numb, cool, or painful. Fingers or toes may change color from pale, to blue, to red. Tell your HCP if you or your child have any numbness, pain, skin color change, or sensitivity to temperature in the fingers or toes. Call your HCP right away if you or your child have any signs of unexplained wounds appearing on fingers or toes while using XELSTRYM.
  • Serotonin syndrome. Symptoms such as agitation, fast heartbeat, flushing, seizures, coma, sweating, loss of coordination, confusion, dizziness, tremors, stiff muscles, muscle twitching, seeing or hearing things that are not real (hallucinations), changes in blood pressure, high body temperature (hyperthermia), nausea, vomiting, or diarrhea may occur. Stop using XELSTRYM and call your HCP or go to the emergency room if symptoms occur. Serotonin syndrome may occur if XELSTRYM is taken with certain medicines and may be life-threatening.
  • Allergic skin rash (contact sensitization). Stop using XELSTRYM and tell your HCP right away if you or your child develop swelling or blisters at or around the application site.
  • Application site reactions. Reactions have happened while wearing XELSTRYM and after removing it. Symptoms include pain, itching, burning feeling, redness, discomfort, or swelling at the application site. Call your HCP if you or your child develop any application site reactions that do not resolve on their own.
  • New or worsening tics or worsening Tourette’s syndrome. Tell your HCP if you or your child get any new or worsening tics or worsening Tourette’s syndrome during treatment with XELSTRYM.
Before taking XELSTRYM tell your HCP about all the medications you take and any medical conditions including if you:
  • Are pregnant or plan to become pregnant. It is not known if XELSTRYM may harm your unborn baby. There is a pregnancy registry for women who are exposed to XELSTRYM during pregnancy. The purpose of the registry is to collect information about the health of women exposed to XELSTRYM and their babies. For more information on registering with the National Pregnancy Registry for Psychiatric Medications call 1-866-961-2388 or visit online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/othermedications/
  • Are breastfeeding or plan to breastfeed. XELSTRYM can pass into your milk. Do not breastfeed while taking XELSTRYM. Talk to your doctor about the best way to feed your baby if you take XELSTRYM.
What should I avoid while using XELSTRYM?
  • Do not drive, operate heavy machinery, or do other potentially dangerous activities until you know how XELSTRYM affects you.
  • Avoid exposing the application site to direct external heat sources such as hair dryers, heating pads, electric blankets, heat lamps, saunas, hot tubs, and heated water beds, as exposure to heat can cause too much medicine to pass into your body and cause serious side effects.
The most common side effects of XELSTRYM include:
  • decreased appetite
  • trouble sleeping
  • stomach pain
  • nausea
  • increased blood pressure
  • headache
  • muscle twitching (tics)
  • vomiting
  • irritability
  • increased heart rate

Please click here for the Medication Guide and Full Prescribing Information, including the BOXED WARNING.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Important Safety Information
What is XELSTRYM?

XELSTRYM is a central nervous system stimulant prescription medicine used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD) in adults and children 6 years and older. XELSTRYM may help increase attention and decrease impulsiveness and hyperactivity in adults and children 6 years of age and older with ADHD. XELSTRYM is not recommended for use in children under 6 years of age with ADHD.

IMPORTANT SAFETY INFORMATION

Abuse, misuse, and addiction: XELSTRYM is a federally controlled substance (CII) because it contains dextroamphetamine that can be a target for people who abuse prescription medicines or street drugs. Keep XELSTRYM in a safe place to protect it from theft. Never sell or give your XELSTRYM to anyone else because it may cause death or harm to them and it is against the law. Tell your healthcare provider (HCP) if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Do not use XELSTRYM if you or your child are:
  • Allergic to amphetamine or any of the ingredients in XELSTRYM. See the end of the Medication Guide for a complete list of ingredients in XELSTRYM.
  • Taking or have taken within the past 14 days a medicine called a monoamine oxidase inhibitor (MAOI), including the antibiotic linezolid or the intravenous medicine called methylene blue.
XELSTRYM can cause serious side effects, including:
  • Risks for people with serious heart disease. Sudden death has happened in people who have heart defects or other serious heart disease. Your HCP should check you or your child carefully for heart problems before starting treatment with XELSTRYM. Tell your HCP if you or your child have any heart problems, heart disease, or heart defects. Call your HCP or go to the nearest hospital emergency room right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting during treatment with XELSTRYM.
  • Increased blood pressure and heart rate. Your HCP should check you or your child’s blood pressure and heart rate regularly during treatment with XELSTRYM.
  • Mental (psychiatric) problems. Including new or worse behavior and thought problems; new or worse bipolar illness; new psychotic symptoms (such as hearing voices, or seeing or believing things that are not real); or new manic symptoms. Tell your HCP about any mental problems you or your child have or about a family history of suicide, bipolar illness, or depression. Call your HCP right away if you or your child have any new or worsening mental symptoms or problems during treatment with XELSTRYM, especially hearing, seeing or believing things that are not real, or new manic symptoms.
  • Slowing of growth (height or weight) in children. Children should have their height and weight checked often while on XELSTRYM. Your HCP may stop treatment with XELSTRYM if your child is not growing or gaining height or weight as expected.
  • Circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud's phenomenon). Fingers or toes may feel numb, cool, or painful. Fingers or toes may change color from pale, to blue, to red. Tell your HCP if you or your child have any numbness, pain, skin color change, or sensitivity to temperature in the fingers or toes. Call your HCP right away if you or your child have any signs of unexplained wounds appearing on fingers or toes while using XELSTRYM.
  • Serotonin syndrome. Symptoms such as agitation, fast heartbeat, flushing, seizures, coma, sweating, loss of coordination, confusion, dizziness, tremors, stiff muscles, muscle twitching, seeing or hearing things that are not real (hallucinations), changes in blood pressure, high body temperature (hyperthermia), nausea, vomiting, or diarrhea may occur. Stop using XELSTRYM and call your HCP or go to the emergency room if symptoms occur. Serotonin syndrome may occur if XELSTRYM is taken with certain medicines and may be life-threatening.
  • Allergic skin rash (contact sensitization). Stop using XELSTRYM and tell your HCP right away if you or your child develop swelling or blisters at or around the application site.
  • Application site reactions. Reactions have happened while wearing XELSTRYM and after removing it. Symptoms include pain, itching, burning feeling, redness, discomfort, or swelling at the application site. Call your HCP if you or your child develop any application site reactions that do not resolve on their own.
  • New or worsening tics or worsening Tourette’s syndrome. Tell your HCP if you or your child get any new or worsening tics or worsening Tourette’s syndrome during treatment with XELSTRYM.
Before taking XELSTRYM tell your HCP about all the medications you take and any medical conditions including if you:
  • Are pregnant or plan to become pregnant. It is not known if XELSTRYM may harm your unborn baby. There is a pregnancy registry for women who are exposed to XELSTRYM during pregnancy. The purpose of the registry is to collect information about the health of women exposed to XELSTRYM and their babies. For more information on registering with the National Pregnancy Registry for Psychiatric Medications call 1-866-961-2388 or visit online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/othermedications/
  • Are breastfeeding or plan to breastfeed. XELSTRYM can pass into your milk. Do not breastfeed while taking XELSTRYM. Talk to your doctor about the best way to feed your baby if you take XELSTRYM.
What should I avoid while using XELSTRYM?
  • Do not drive, operate heavy machinery, or do other potentially dangerous activities until you know how XELSTRYM affects you.
  • Avoid exposing the application site to direct external heat sources such as hair dryers, heating pads, electric blankets, heat lamps, saunas, hot tubs, and heated water beds, as exposure to heat can cause too much medicine to pass into your body and cause serious side effects.
The most common side effects of XELSTRYM include:
  • decreased appetite
  • trouble sleeping
  • stomach pain
  • nausea
  • increased blood pressure
  • headache
  • muscle twitching (tics)
  • vomiting
  • irritability
  • increased heart rate

Please click here for the Medication Guide and Full Prescribing Information, including the BOXED WARNING.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.